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Intagra is used to treat sexual frustration. The formula contains a superpotent ingredient called Sildenafil. It is aimed to amplify smooth muscle relaxation with the help of nitric oxide. The smooth muscle relaxation directs the blood flow into the area of the penis and that causes an erection.
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Treatment of erectile dysfunction, defined as inability to achieve and maintain penile erection required for successful sexual intercourse.
For effective action Intagra IP you need sexual arousal.
Hypersensitivity to the active substance or to any component of the drug.
Due to the influence on the exchange of nitric oxide / guanosine monophosphate, (cGMP) sildenafil enhances the hypotensive effect of nitrates, so their joint appointment is contraindicated with nitric oxide donors (such as amyl nitrite) or nitrates in any form.
Patients for whom sexual activity is undesirable should not use drugs for the treatment of erectile dysfunction, including sildenafil, (e.g. patients with severe cardiovascular disease such as unstable angina or severe cardiac failure).
Receiving sildenafil is contraindicated in patients who have lost vision in one eye through partiranno anterior ischemic optic neuropathy, regardless of whether it happened because of the previous reception of an inhibitor phosphodiesterase type 5.
For oral use adults.
The recommended dose is 50 mg taken when needed approximately 1:00 to sexual activity. Given the efficacy and tolerability, the dose can be increased to 100 mg or decrease to 25 mg. the Maximum recommended dose of 100 mg.
The maximum recommended frequency of reception - 1 time per day. The effectiveness of the drug may be delayed when taken with food compared with fasting.
Patients of advanced age.
For elderly patients dose adjustment is not required.
Patients with impaired renal function.
Patients with renal insufficiency mild to moderate severity (creatinine clearance 30-80 ml / min) dosage regimen is not changed. Because patients with severe renal insufficiency (creatinine clearance <30 ml / min) sildenafil clearance is reduced, the use of the drug should start with a dose of 25 mg.
Patients with impaired liver function.
Because patients with hepatic impairment, sildenafil clearance was reduced, such as cirrhosis, use preparation should begin with a dose of 25 mg.
Patients who use other treatments.
Given the degree of interaction in patients receiving therapy with ritonavir, it is recommended not to exceed a maximum single dose of 25 mg sildenafil within 48 hours. The starting dose of 25 mg is recommended in patients receiving concomitant treatment with CYP3A4 inhibitors (e.g. erythromycin, saquinavir, ketoconazole, Itraconazole).
With the aim of decreasing, the risk of postural hypotension should achieve stabilization of patients during therapy with a-blocker to the use of sildenafil. In addition, you should begin the assignment with a dose of sildenafil 25 mg.
During studies, side effects were transient, mild to moderate degree. The frequency and severity of side effects was growing with increasing doses. Nature of side effects in studies of variable dose increasingly reflects the recommended dosage regimen, was similar to the studies with a fixed dose. The most common side effects were headache, flushing, dyspepsia, visual disturbances, nasal congestion, dizziness and disturbance of color vision.
The immune system: rarely - hypersensitivity reactions, including skin rashes.
From the nervous system: very often - headache; often - dizziness, rarely - drowsiness, hypoesthesia; rare - cerebrovascular attack, fainting; unknown - transient ischemic attack, epileptic seizure, recurrence of epileptic seizure, convulsions.
On the part of the organ of vision: often - abnormal vision (blurred vision, hypersensitivity to light), chromatopsia (moderate, transient, mostly color vision), rarely - breach on the part of the conjunctiva, eye pain, eye redness, lacrimation disorders, other disturbances; unknown - partitially anterior ischemic neuropathy of the optic nerve, occlusion of retinal vessels, visual field defects.
Organs of hearing: infrequent - vertigo, tinnitus rare deafness .
Cardio-vascular system: often - vasodilatation (flushing) often palpitation (palpitations) uncommon - tachycardia, tachycardia, rarely - arterial hypertension / hypotension, myocardial infarction, atrial fibrillation not known - ventricular arrhythmias, unstable angina, sudden cardiac death, syncope.
In applying the drug in doses exceeding recommended, undesirable effects were similar, but occurred more often.
The use of sildenafil had no effect on the incidence of myocardial infarction and mortality rate from cardiovascular diseases.
In studies on healthy volunteers when a single reception sildenafil in doses up to 800 mg adverse effects were similar to those observed at lower doses of the drug, but the frequency of their occurrence and severity increased. Increase dose to 200 mg did not cause an increase in efficiency, but has caused the emergence of a large number of adverse reactions (headache, flushing, dizziness, dyspepsia, nasal congestion, abnormal vision) compared with lower doses.
Treatment. In case of overdosage should, if necessary, apply symptomatic therapy. It should be noted that dialysis could not speed up the excretion of the drug, as sildenafil binds strongly to plasma proteins and is not excreted in the urine.
Use during pregnancy or breastfeeding
The drug Intagra IP does not apply to women.
The drug Intagra is not prescribed to children.